Nephrin AKTs on actin: The slit diaphragm–actin cytoskeleton signaling network expands
نویسندگان
چکیده
منابع مشابه
The podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton
Nephrin is an Ig-like transmembrane protein. It is a major component of the podocyte slit-diaphragm and is essential for maintaining normal glomerular permeability. CD2-associated protein (CD2AP) is also necessary for normal glomerular permeability and is a putative nephrin adapter molecule. Here we document that nephrin and CD2AP are linked to the actin cytoskeleton. As detected by western blo...
متن کاملPodocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton.
Nephrin is an Ig-like transmembrane protein. It is a major component of the podocyte slit diaphragm and is essential for maintaining normal glomerular permeability. CD2-associated protein (CD2AP) is also necessary for normal glomerular permeability and is a putative nephrin adapter molecule. Here, we document that nephrin and CD2AP are linked to the actin cytoskeleton. As detected by Western bl...
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Chemotaxis is crucial for many physiological processes including the recruitment of leukocytes to sites of infection, trafficking of lymphocytes in the human body, and metastasis of cancer cells. A family of small proteins, chemokines, serves as the signals, and a family of G-protein coupled receptors (GPCRs) detects chemokines and direct cell migration. One of the basic questions in chemotaxis...
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Hemopexin is an abundant plasma protein that effectively scavenges heme. When infused into rats, hemopexin induces reversible proteinuria, and activated hemopexin is increased in children with minimal change nephrotic syndrome. These observations suggest a role for hemopexin in glomerular disease; in this study, the effects of active hemopexin on human podocytes and glomerular endothelial cells...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2008
ISSN: 0085-2538
DOI: 10.1038/sj.ki.5002741